Histamine is the chemical that’s largely responsible for the trademark allergic reaction. Histamine Intolerance GERD Solutions GERD (Gastroesophageal Reflux Disease) or “acid reflux” is a common complaint among those with mast cell or histamine disorders. Benadryl (an over-the-counter antihistamine) may be useful if you accidentally eat a histamine-containing food or have to take a drug that can block histamine-processing enzyme activity. It took almost a year to self-diagnose the issue and, this diagnosis only came accidentally, because I happened to stumble upon a single case of histamine intolerance during my Master of Science studies. H2 histamine blockers help the stomach lining.... and I believe relieve some or a lot of acid reflux. Histamine is the chemical transmitter that stimulates the parietal cells to release gastric acid. ascorbic, citric, malic, acetic, etc. (Read more about these symptoms.) When I was 23, I became histamine intolerant - what appeared to be quite suddenly, actually. So I have the feeling that in my case, the hiatal hernia is the only potential visible cause for GERD, but since I didn't get lesions or anything, I think that this is a side diagnosis, and the wrong reason for my GERD and that it is purely related to histamine. Famotidine reduces the secretion of gastric acid in the stomach by blocking the effect of histamine on histamine H2-receptors located on the parietal cells lining the stomach wall. Many people think the only answer is a pharmaceutical drug –usually a histamine H2 blocker or a Proton Pump Inhibitor (PPI). Results Murine and human mast cells treated with omeprazole exhibited diminished degranulation and release of cytokines and histamine in response to allergen. The great thing about getting off of Omeprazole is that Zantac has an H2 histamine blocker for the stomach. Histamine-2 receptor antagonist drugs (like ranitidine) block the histamine receptor and do nothing for the level of histamine in the body. Histamine intolerance: a metabolic disease? I have always had IBS and fibro, and food intolerances from birth. A buildup in the body can happen because of excess histamine but also insufficient DAO levels. I am on a strict organic, low hist, unprocessed diet, but have been troubled my entire life with intolerance to all fruit and acids, incl. So if you are able to get off of Omeprazole, it might be possible to eat some more foods with Zantac. Food sensitivities including histamine intolerance, IBS and thyroid CA as well as ADHD run in the family. While a histamine-free diet is the only long-term treatment for histamine intolerance, there are a couple of other treatments that may be useful. When histamine runs rampant and unchecked, it can cause health complications like histamine intolerance and mast cell activation syndrome. Res. There are 3 major pathways in the body that breakdown histamine. I've seen that histamine intolerance can create a bloated belly, but also trigger GERD. H. G. Schwelberger Inflamm. Essentially, it is when our body is sensitive to the level of histamine - when the level is hovering around the "full" level of the jar, so that any addition will cause it to overflow. The effects of omeprazole on these responses were investigated as was its impact on mast cell–dependent anaphylaxis and food allergy phenotypes in vivo. Histamine Intolerance and Mast Cell Activation Syndrome can produce similar symptoms. Histamine Intolerance is when your body has too much histamine. But there is a difference between Histamine Intolerance and Mast Cell Activation Syndrome. In comparisons with histamine H 2-receptor antagonists in patients with EE, grade 2 or above, Omeprazole in a dose of 20 mg was significantly more effective than the active controls.